Preparation of low-molecular-weight hyaluronan using ultrasonic degradation

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The hyaluronan at different concentrations were degraded in ultrasonic oscillator by changing ultrasonic frequency, water bath temperature and pH value. The hyaluronan at the concentration of 2.0 g/L degraded at the highest rates. High ultrasonic frequency and low temperature were propitious to hyaluronan degradation, while the pH value had little influence on it. Moreover, acid condition was a little more convenient for hyaluronan degradation than neutral and basic conditions.

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