To study biocompatibility of cardiovascular stent materials.METHODS:
Articles about randomized controlled animal experiments and clinical applications which were focus on the biocompatibility of cardiovascular stent materials were collected from Medline database and CNKI from 1998 to 2008. And then, those articles were summed up based on experimental animals, grouping, materials, methods, results, and conclusions. Furthermore, clinical subjects received cardiovascular stent were generally analyzed, and following up and functional evaluation were performed to overall summarize the biocompatibility of cardiovascular stent materials.RESULTS:
Six out of nine articles suggested that dogs and pigs were the major experimental animals, and the biocompatibility of drug coating was well, the incidence of restenosis was low, being ideal cardiovascular stent materials. Three clinical articles suggested that there were no significant differences between age, sex, and injured region of drug coating during clinical application. Evaluation criterion demonstrated that coating stent could decrease inflammatory reaction, restenosis occurrence, and cardiovascular incidence.CONCLUSION:
Drug coating is an excellent cardiovascular stent material with good biocompatibility.