SymbolBone marrow mesenchymal stem cells improve cardiomyocyte contractility in rats with heart failure

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Bone marrow mesenchymal stem cells (BMSCs) transplantation can significantly improve cardiac function.


To investigate the effect of BMSCs on cardiomyocytes contractility and dilatation in rats with heart failure after myocardial infarction.


Left anterior descending coronary arteries of 10 Sprague Dawley rats were ligated in order to establish the myocardial ischemia model. The model rats were randomly divided into two groups: the experimental group and the control group. Four weeks later, 5 × 106/L PKH26 labeled BMSCs were injected into the infracted myocardium in the experimental group and in the control group, only injected with PBS.


Compared with ligation, the cardiac function in two groups after modeling for 4 weeks was improved significantly (P < 0.01). After treated with BMSCs administration, the cardiac function in experimental group was improved significantly (P < 0.05). The amplitude of shortening/relengthening and contractile velocity of cardiomyocytes in experimental group was significantly increased (P < 0.01). The cardiomyocytes with contractility differentiated from BMSCs could be seen under fluorescence microscope. The injection of BMSCs could significantly increase the shortening/relengthening function of rat cardiomyocytes and was one of the important mechanisms in BMSCs improved of heart failure rats.

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