The pervious study has showed that placenta mesenchymal stem cells (PMSCs) can differentiate into bone, cartilage, and muscle and adipose mesenchymal stem cells.OBJECTIVE:
To investigate the differentiation of PMSCs into epidermal cells in vitro.METHODS:
PMSCs were isolated and cultured and the surface antigen was detected by flow cytometry.RESULTS AND CONCLUSION:
Isolated PMSCs were positive for the markers CD105, CD29 and CD44 and negative for typical hematopoietic and endothelial markers CD34, CD45, CD106 and HLA-DR. The morphology of induced cells was obviously changed. Immunohistochemistry stain analysis showed positive for epidermal-specific markers like CK19 and CK10. The PMSCs have the capability to differentiate into epidermal cells in vitro. The placenta may prove to be a useful source of mesenchymal stem cells in skin tissue engineering and stem cells study.