SymbolDifferentiation of bone marrow mesenchymal stem cells into endothelial cells and clinical application

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Abstract

BACKGROUND:

Studies have preliminarily verified that the bone marrow mesenchymal stem cells (BMSCs) can differentiate into endothelial cells.

OBJECTIVE:

To review the differentiation of BMSCs into endothelial cells and the progress of clinical research.

METHODS:

PubMed database was searched for articles published from 2000 to 2011 with the key words of “bone marrow mesenchymal stem cell, endothelial cell, differentiation, tissue engineered. The language was limited in English. Meanwhile, Wanfang database was searched for articles published from 2000 to 2011 with the key words of “bone marrow mesenchymal stem cell, endothelial cell, differentiation, clinical application” in Chinese.Totally 418 articles were retrieved, and finally 31 articles were included.

RESULTS AND CONCLUSION:

BMSCs have the potential of self renewal and multiplex differentiation. In certain conditions, they can be induced into endothelial cells. Endothelial cells are the important components of tissue-engineered blood vessels. BMSCs for endothelial construction can promote the regeneration of blood vessels in tissue-engineered organs, provide blood supply and also lay the foundation for the treatment of ischemic diseases in clinic.

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