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Abstract

BACKGROUND:

So far, research on hormone-induced avascular necrosis of the femoral head does not involve cell function change induced by the alteration of osteoblast and osteoclast.

OBJECTIVE:

To investigate bone metabolism and bone tissue pathological changes of hormone-induced avascular necrosis of the femoral head in rabbits.

METHODS:

A number of 32 New Zealand white rabbits were randomly divided into two groups, control group and model group. The model rabbits were injected with 8.0 mg/kg hydrocortisone acetate twice a week for 8 weeks to produce avascular necrosis model of the femoral head. The control rabbits were injected with equivalent physiological saline.

RESULTS AND CONCLUSION:

Compared with the control group, the serum calcium and phosphate level of model group dropped significantly since the 2nd week (P < 0.05), while the enzymatic activity of tartrate-resistant acid phosphatase rised significantly (P < 0.05). Bone specific alkaline phosphatase level of model group increased while bone gla protein level decreased at the start of the 4th week (P < 0.05). Bone specific alkaline phosphatase level of model group declined by the 8th week. Compared with the contrl group, the femoral intertrochanter bone mineral density of model group dropped since the 2nd week (P < 0.05), and the bone mineral density of femoral head dropped since the 4th week (P < 0.05). From the 4th week, the amount of osteoblast decreased significantly, while the osteoclast amount increased significantly (P < 0.05). These results suggest that hormone can damage bone shaping and bone remodeling by damaging bone cells, reduce the content of mineral salt used for bone formation, and lead to hormone-induced avascular necrosis of the femoral head.

RESULTS AND CONCLUSION:

Yang WQ, Jiang ZG, Huang CL. Bone tissue function and pathological changes of hormone-induced avascular necrosis of the femoral head in rabbits. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9319-9322. [http://http://www.crter.cn http://en.zglckf.com]

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