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Abstract

BACKGROUND:

Human immunodeficiency virus binds to CD4 receptors in human thymocytes, and thus causes activity decreasing in CD4 cells.

OBJECTIVE:

To explore the relationship between human embryo thymocytes and human immunodeficiency virus.

METHODS:

Primary cultured human embryo thymocytes were divided into experiment group and control group. Experimental thymocytes were mixed cultured with human immunodeficiency virus 1 III B. Control thymocytes were cultured without human immunodeficiency virus.

RESULTS AND CONCLUSION:

According to transmission electron microscopy, massive human immunodeficiency virus particles emerged in thymocytes treated with human immunodeficiency virus at the 40th hour after cultivation. According to MTT assay and immunohistochemical staining, the absorbance in thymocytes treated with human immunodeficiency virus was significantly lower than that in the control thymocytes at the 40th hour to the 2nd day after cultivation (r=0.9733, P < 0.05). The Fas-L positive rate of the experiment thymocytes treated with human immunodeficiency virus increased on cell membranes and in cytoplasm (P < 0.05). These findings indicate that human immunodeficiency virus decreases the cell activity in primary cultured human embryo thymocytes.

RESULTS AND CONCLUSION:

Gao NJ, Chen YJ, Li XT, Kong WY, Zhou YP. Interaction between primary cultured human thymocytes and human immunodeficiency virus. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9344-9347. [http://http://www.crter.cn http://en.zglckf.com]

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