SymbolEffect of continuous static hydrostatic pressure on cell proliferation

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BACKGROUND:Vascular smooth muscle cells grow well in culture condition using static hydrostatic pressure instead of serum.OBJECTIVE:To investigate the effect of continuous static hydrostatic pressure on the proliferation of vascular smooth muscle cells.METHODS:Vascular smooth muscle cell A10 and vascular endothelial cell HUVEC-12 were cultured in a self-developed pressure adjustable incubator, under different pressures of 0, 12, 16, 20, 24 and 28 kPa respectively.RESULTS AND CONCLUSION:The most obvious proliferation of A10 cell was detected under the pressure of 16 kPa, with greatest cell activity. And the most obvious proliferation of HUVEC-12 cell was under 20 kPa pressure, with greatest cell activity. It confirms that limited hydrostatic pressure can promote the proliferation of A10 and HUVEC-12 and increase the cell activity.Guo ZF, Feng Y, Li K, Liao DF. Effect of continuous static hydrostatic pressure on cell proliferation. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9353-9355. [http://]

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