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Abstract

BACKGROUND:

Researches on the overall ultrastructural changes of the body parts near and distant from the corticospinal tract lesion are rarely reported.

OBJECTIVE:

To investigate the ultrastructural changes of corticospinal tract in rats after corticospinal tract semitransection.

METHODS:

Rat left vertebral body of medulla was selectively cleavaged to construct corticospinal tract semitransection model. Electron microscopy was utilized to determine the degeneration of the corticospinal tract on the 4th, 14th and 28th days after corticospinal tract semitransection.

RESULTS AND CONCLUSION:

According to transmission electron microscope observation, the myelin sheath and axons of lesioned corticospinal tract were swelling and irregular in shape. Subsequently, during the extended periods, the ultrastructural changes were myelinoclasis, dissolvation in myelin sheath, and demyelination, shrink of cytoplasm, vacuolar degeneration, increase of organelles in axons progressively. These changes of lesioned corticospinal tract at cervical, thoracic, lumbar segments of spinal cord were more serious than those closed to lesion site.

RESULTS AND CONCLUSION:

Liu S, Shen GY, Lü GM. Ultrastructural changes of the corticospinal tract in rats after corticospinal tract semitransection. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9369-9372.

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