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Abstract

BACKGROUND:

Several studies have shown that electro-acupuncture (EA) can effectively alleviate the clinical symptoms of osteoarthritis.

OBJECTIVE:

To investigate the mechanism by which EA treatment inhibits osteoarthritis inflammation and protects the function of articular cartilage.

METHODS:

SD rat models of osteoarthritis were established by double knee joint cavity injection of papain. Osteoarthritis rat models were treated with EA at EX-LE4 and EX-LE5 for 5, 15 and 30 minutes per day.

RESULTS AND CONCLUSION:

Compared with the model group, substance P in blood and interleukin 1, interleukin 6, tumor necrosis factor α, matrix metalloproteinase 3 concentrations in synovial fluid were significantly reduced, leptin in blood and matrix metalloproteinase 1 in synovial fluid were significantly increased (P < 0.05), and the degree of cartilage degeneration was significantly alleviated (P < 0.05, P < 0.01) in osteoarthritis rat models after treatment with EA for 15 and 30 minutes per day (P < 0.05). These results showed that EA can effectively alleviate the inflammatory reaction and postpone articular cartilage degeneration in osteoarthritis.

RESULTS AND CONCLUSION:

Wu MX, Li XH, Wu GW, Li L, Chen WL, Liu XX. Electro-acupuncture treatment inhibits inflammatory reaction and postpones articular cartilage degeneration in osteoarthritis. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9410-9414. [http://http://www.crter.cn http://en.zglckf.com]

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