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Studies have shown that matrix metalloproteinases 3 plays an important role in articular cartilage degeneration and destruction.


To observe the changes of metalloproteinases 3 expression level in synovium of knee osteoarthritis rats after treated with penetration needling of long needle and sodium hyaluronate.


SD rats were injected with 1.6% papain solution to knee joint cavity and were driven to exercise in order to construct knee osteoarthritis model. Rats were randomly assigned into 3 groups in the 2nd week after model construction: penetration needling group, drug group and model group. Penetration needling group were treated by penetration needling with filiform needle, with a diameter of 0.30 millimeters and a length of 125 milimeters. Drug group were injected with sodium hyaluronate to knee joint cavity. Model group received no treatment. And non-model control group were established.


Content of synovium matrix metalloproteinase 3 in model group was significantly increased than that in the control group (P < 0.05) in the 4th week after treatment. The content of matrix metalloproteinase 3 in penetration needling group and drug group was significantly reduced than that in the model group (P < 0.05). Penetration needling group was similar to drug group (P > 0.05). These findings demonstrate that long needle penetration therapy can effectively correct the abnormal expression of matrix metalloproteinase 3 in synovium of knee osteoarthritis model rats. It may be one of the mechanisms of the treatment of knee osteoarthritis by long needle penetration needling.


Li SS, Wu YC, Zhang JF, Zhou JH, Sun YJ, Huang CF. Effect of long needle penetration needling on matrix metalloproteinase 3 in the synovium of knee osteoarthritis model rats. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9415-9418. [http://]

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