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Abstract

BACKGROUND:

Studies have shown that matrix metalloproteinases 3 plays an important role in articular cartilage degeneration and destruction.

OBJECTIVE:

To observe the changes of metalloproteinases 3 expression level in synovium of knee osteoarthritis rats after treated with penetration needling of long needle and sodium hyaluronate.

METHODS:

SD rats were injected with 1.6% papain solution to knee joint cavity and were driven to exercise in order to construct knee osteoarthritis model. Rats were randomly assigned into 3 groups in the 2nd week after model construction: penetration needling group, drug group and model group. Penetration needling group were treated by penetration needling with filiform needle, with a diameter of 0.30 millimeters and a length of 125 milimeters. Drug group were injected with sodium hyaluronate to knee joint cavity. Model group received no treatment. And non-model control group were established.

RESULTS AND CONCLUSION:

Content of synovium matrix metalloproteinase 3 in model group was significantly increased than that in the control group (P < 0.05) in the 4th week after treatment. The content of matrix metalloproteinase 3 in penetration needling group and drug group was significantly reduced than that in the model group (P < 0.05). Penetration needling group was similar to drug group (P > 0.05). These findings demonstrate that long needle penetration therapy can effectively correct the abnormal expression of matrix metalloproteinase 3 in synovium of knee osteoarthritis model rats. It may be one of the mechanisms of the treatment of knee osteoarthritis by long needle penetration needling.

RESULTS AND CONCLUSION:

Li SS, Wu YC, Zhang JF, Zhou JH, Sun YJ, Huang CF. Effect of long needle penetration needling on matrix metalloproteinase 3 in the synovium of knee osteoarthritis model rats. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9415-9418. [http://http://www.crter.cn http://en.zglckf.com]

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