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Abstract

BACKGROUND:

Extensive research has been done on the function of the periodontal ligament under the orthodontic force. However, there are no reports regarding the expression of Toll-like receptor 4 in rat periodontium during orthodontic tooth movement.

OBJECTIVE:

To investigate the expression of Toll-like receptor 4 in rat periodontium during orthodontic tooth movement.

METHODS:

Rat orthodontic tooth movement model was constructed using NiTi extension spring with the force value of 50 g. The orthodontic periodontium was collected on the 1st, 3rd, 5th, 7th, 10th and 14th days after exerting force to detect the expression of Toll-like receptor 4.

RESULTS AND CONCLUSION:

According to immunofluorescence staining, the expression of Toll-like receptor 4 in the periodontal tissues increased on the 1st day after exerting force, and reached highest level on the 5th day; then fell to the initial level on the 14th day. Thus the expression of Toll-like receptor 4 is evoked by orthodontic force, and it may play a role in periodontal remodeling.

RESULTS AND CONCLUSION:

Nie J, Zhong LJ, Li XB, Lin BS, Qian X, Qian YJ. Expression of Toll-like receptor 4 in rat periodontal ligament during orthodontic tooth movement. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9453-9456. [http://http://www.crter.cn http://en.zglckf.com]

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