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Abstract

BACKGROUND:

Sodium tanshinone II A sulfonate (STS) play effects on anti-oxidant, and depression of fibration.

OBJECTIVE:

To investigate the effect of early injection of STS on hypertrophic scar (HS) of rabbit ear.

METHODS:

Scar model were established by removing the skin and perichondrium in rabbits ears on facies ventralis. STS 0.05 mg, 0.1 mg, 0.2 mg (or 40μl normal saline, respectively, experimental groups), normal saline 40 μL(control group) were injected into early rabbits ears scars, once a week, 3 weeks all together.

RESULTS AND CONCLUSION:

After 3 weeks STS injection, the hyperplasia and the thickness were decreased; the quantity of collagen fiber and vascular in scar tissue section was decreased in experimental group detected by hematoxylin-eosin staining. The collagen fiber area in scar tissue section was decreased by Masson staining and the amount and the volume of fibroblast were decreased under electron microscope. That indicated that early STS injection could depress HS in rabbits scar ears.

RESULTS AND CONCLUSION:

Zhang JH, Ou BX, Meng CY. Early application of sodium tanshinone II A sulfonate can depress hypertrophic scar of rabbit ear. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9457-9461. [http://http://www.crter.cn http://en.zglckf.com]

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