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Abstract

BACKGROUND:

Osteoporosis is a polygenic disease, and the peak bone mass and bone mass loss are significantly determined by genetics factors.

OBJECTIVE:

To determine the genotype frequencies of Vitamin D receptor gene Apa I polymorphism and its association with osteoporosis of han population in Shandong Peninsula, and then to approach the predisposing factors of primary osteoporosis.

METHODS:

A total of 367 han people coming from unrelated familes who lived in Shandong Peninsula for many years were selected. The subjects were divided into normal bone mineral density group (n=227), osteoporosis group (n=63) and ospteoporosis with osteoporotic fracture group (n=77).

RESULTS AND CONCLUSION:

The genotype frequency distribution of Vitamin D receptor gene followed the Hardy-Weinberg equilibrium (χ2 =1.583, P > 0.05). The frequency distribution of genotypes aa, Aa and AA were 53.1%, 10.6 % and 36.3%, respectively. Body mass index had significant positive correlation with bone mineral density (P < 0.01), while age had significant negative correlation with bone mineral density (P < 0.01). People with aa genotype had significant lower bone mineral density in lumbar spine and ward’s triangle (P < 0. 05) after correcting the body mass index and age. According to χ2 test, there was no significant difference between osteoporotic fracture group and normal control group (χ2 =4.795, P > 0.05). The experimental results show that there is possible correlation between polymorphisms of restriction sites in Vitamin D receptor gene Apa I and bone mineral density in han people of Shandong Peninsula. It indicates that the restriction site polymorphisms of Apa I gene may be used as genetic markers in predicting the risk of developing osteoporosis.

RESULTS AND CONCLUSION:

Luan JW, Fan XH, Chen ZW. Correlation between Vitamin D receptor gene polymorphism and osteoporosis. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9486-9490. [http://http://www.crter.cn http://en.zglckf.com]

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