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Abstract

BACKGROUND:

FOXC2 is closely related to the differentiation of adipose cells. It plays an important role in many aspects, such as energy metabolism, resistance of type II diabetes and metabolic syndrome.

OBJECTIVE:

To investigate the expression level of FOXC2 mRNA in human ventral adipose tissue of Yunnan Province, and to explore the relations between FOXC2 and type II diabetes.

METHODS:

Type II diabetic patients or nondiabetic patients underwent abdominal surgery in Affiliated Hospital of Kunming Medical University were randomly selected as experimental subjects, with 50 cases in each group. The expression level of FOXC2 mRNA in ventral adipose tissue was detected by RT-PCR. The correlation of FOXC2 mRNA expression and subject clinical data was analyzed.

RESULTS AND CONCLUSION:

The expression level of FOXC2 mRNA in ventral adipose tissue in type II diabetic patients decreased. The FOXC2 mRNA expression level of diabetic group was inversely related to fasting blood-glucose and blood pressure. The FOXC2 mRNA expression level of nondiabetic group was inversely related to fasting blood-glucose. These findings indicate that FOXC2 may reduce insulin resistance and improve the regulation of insulin on sugar metabolism in type II diabetic patients. In addition, the decrease of FOXC2 expression shows a synergetic effect on blood press raise in diabetic patients.

RESULTS AND CONCLUSION:

Nian X, Wei JJ, Su YD, Liu H, Zhang XX, Li H. Relations between the expression level of FOXC2 mRNA in ventral adipose tissue and type 2 diabetes. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(50): 9496-9500. [http://http://www.crter.cn http://en.zglckf.com]

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