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Abstract

BACKGROUND:

The ideal degradation rate of bone repair materials should be matched with the speed of new bone formation, and the bone repair materials are replaced by new bone gradually via creeping substitution.

OBJECTIVE:

To investigate the in vitro degradation mechanism and degradation speed of β-tricalcium phosphate/α-calcium sulphate hemihydrates (β-TCP/α-CSH) bone graft.

METHODS:

β-TCP/α-CSH, β-TCP and α-CSH samples were soaked in PBS liquid. The pH value, degradation rate and compressive stress were examined.

RESULTS AND CONCLUSION:

In the PBS liquid, the pH value of β-TCP/α-CSH bone graft and α-CSH gradually decreased with the soaked time, but that of β-TCP changed little. After 4 weeks, the pH value of β-TCP/α-CSH bone graft and α-CSH was stabilized to about 5.6. The weight and compressive stress of β-TCP/α-CSH bone graft and α-CSH were gradually decreased with the soaked time in the PBS liquid, but those of β-TCP decreased little. β-TCP/α-CSH bone graft can gradually degrade through physical dissolution in vitro, and the degradation rate is lower than that of β-TCP but higher than that of α-CSH.

RESULTS AND CONCLUSION:

Li P, Mao KY, Jiang T, Yang Y, Cui FZ, Hou XJ, Liang MH, Du MK, Wang JF, Wang Y. In vitro degradation mechanism of beta-tricalcium phosphate/alpha-calcium sulfate hemihydrates bone graft. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(51): 9501-9504. [http://www.crter.cnhttp://en.zglckf.com]

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