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Degradation properties of scaffold are closely related to the adhering of seed cells to its surface.


To prepare the composite membrane of porous poly (3-hydroxybutyrate-co-4-hydroxybutyrate)/calcium metaphosphate (P (3HB-co-4HB)/CMP) and observe its degradation properties in vitro.


The raw material ratio of P (3HB-co-4HB)/CMP was 50/50, and the P (3HB-co-4HB)/CMP was mixed uniformly and dissolved in chloroform and dumped in a Petri dish. After drying, the porous composite membranes were obtained. The porous composite membranes were put in the circulation device, the flow rate of which was 0.30 m/s, the channel was filled with 50 mL 37 °C physiological saline.


Weight loss rates of the composite membrane at 2, 4, 8, 16, 24 hours under flow field were 4.5%, 5.6%, 6.9%, 9.6% and 10.6% respectively; scanning electron microscopy showed that the partial calcium phosphate particles on the surfaces were complete depredated or lost, the concave particles were kept, 2 μm porous on the surfaces could not be seen, 30-50 μm porous did not change but the edge was smooth; the water absorption, porosity and density of the composite membrane were 40.6%, 46.3%, and 1.14 g/cm3 respectively before depredation, and 51.6%, 54.1%, 1.05 g/cm3 after that. During the preparation of P (3HB-co-4HB)/CMP, the depredation of the composite membrane in the early stage is the partial calcium phosphate depredation, and the microfilament is prone to be depredated and facture during the depredation.


Wu YH, Zhang LM, Zeng XJ, Mai LP, Wu CL, Tang SQ, Yu XY. Preparation and degradation property of composite membrane of porous poly (3-hydroxybutyrate-co-4-hydroxybutyrate)/calcium metaphosphate. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(51): 9531-9534. [http://www.crter.cn]

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