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Studies in vitro have confirmed that collagen-chitosan (80:20) compound nanofiber membranes have excellent mechanical properties, biocompatibility and biodegradability. However, there are few researches in vivo about the materials.


To observe the effect of collagen-chitosan compound nanofiber membranes on repair of full-thickness skin defect on the back of Sprague Dawley (SD) rats.


Thirty SD rats with full-thickness skin defects on the back were divided into two groups randomly by lottery method. SD rats treated with collogen-chitosan (80:20) compound nanofiber membrane and oily gauzes on the defects were taken as the experimental group, while those treated with oily gauzes only as the control group. The defects of all rats were fixed with dry gauze bandage at the margin of outer packaging.


The wounds healed basically in the experimental group at 14 days after the repair; hematoxylin-eosin staining showed that the numbers of capillaries were reduced and the content of fibers was increased. While in the control group, wound healed irregularly, and the wound was larger than that in the experimental group; hematoxylin-eosin staining showed that there were more obvious dilated capillaries and a large number of inflammatory cells. The above results indicated that collagen-chitosan compound nanofiber membrane is superior to ordinary gauze in promoting the tissue repair and wound healing of skin defects.

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