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Fe3O4 nanoparticles have good magnetic properties, SiO2 has good biocompatibility, and Fe3O4@SiO2 composite nanoparticles are expected to become the carrier of targeted therapy.


To prepare the biocompatible Fe3O4@SiO2 nanoparticles via a reverse microemulsion.


Firstly, hydrophobicity Fe3O4 nanoparticle modified oleic acid were prepared via a one-pot chemical coprecipitation with FeCl3·6H2O, FeCl2·4H2O, oleic acid and NH3H2O. Subsequently, Fe3O4 nanoparticles stabilized with oleic acid were dispersed in cyclohexane, and then Triton-X100, hexylalcohol and H2O were added into the above solution and stirred to form stable reverse microemulsion; In the reverse microemulsion, using ammonia solution as a catalyst, tetraethyl orthosilicate (TEOS) was hydrolyzed and condensed to form Fe3O4@SiO2 compound nanoparticles.


①The structure of Fe3O4 nanopartides prepared by a one-pot chemical coprecipitation was spinel, having a mean diameter of 3.5 nm; Through microemulsion methods, SiO2 were coated successfully on the surface of Fe3O4 nanopartides, and the uniform Fe3O4@SiO2 nanoparticles with a mean diameter of 40 nm were obtained. ②Although the saturation magnetization decreased after Fe3O4 nanopartides being coated, the coercivity of magnetic nanoparticles was near zero before and after encapsulation, revealing Fe3O4 and Fe3O4@SiO2 nanoparticles are of superparamagnetic properties.③ After EA. hy926 cells were cultured accompanied with Fe3O4@SiO2 nanoparticals, the absorbance value of Fe3O4@SiO2 nanoparticles was markedly higher than that of control group (P < 0.05); At 48 and 72 hours of cell culture, no significant difference was found in the absorbance value between the two group (P > 0.05). The results showed Fe3O4@SiO2 compound nanoparticle using a reverse microemulsion is a kind of excellent biomaterial because of its stable, dispersive and superparamagnetic properties.


Sun PF, Xie KR, Zhang FW, Jiao ZX, Cao XR. Preparation and characterization of biocompatible Fe3O4@SiO2 nanoparticals. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(51): 9579-9582. [http://www.crter.cn]

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