Symbol.

    loading  Checking for direct PDF access through Ovid

Abstract

BACKGROUND:

Whether as chemotherapy or as a medium of thermotherapy in malignant tumor, the effect and microstructure of Fe3O4 nanoparticles need further studies.

OBJECTIVE:

To analyze the cellular compatibility of Fe3O4 nanoparticles and to investigate the application and problems of Fe3O4 nanoparticles as drug carriers in the chemotherapy of malignant bone tumors.

METHODS:

According to the evaluate criteria and requirement of GB/T 16886. 5-2003 (Part V: cytotoxicity test in vitro, Biological Evaluation for Medical Instrument), the colloidal solution of Fe3O4 nanoparticles conjugated with cetrimonium bromide or polyethylene glycol or sodium oleate was co-cultured with osteosarcoma UMR-16 cells and human fibroblast cells, respectively, hence to assess the cytotoxicity characteristics.

RESULTS AND CONCLUSION:

According the criteria of GB/T16886.5-2003, Fe3O4 nanoparticles conjugated with sodium oleate had good cellular compatibility, whereas, the cellular compatibility of Fe3O4 nanoparticles conjugated with cetrimonium bromide was poor, which were not considered as a drug carrier of chemotherapy drug using in clinical practice. Fe3O4 nanoparticles conjugated with polyethylene glycol had a certain cellular compatibility, which needed further studies used as drug carriers.

RESULTS AND CONCLUSION:

Gong JZ, Tu ZQ, Duan H, Zhou SB. Cellular compatibility of Fe3O4 nanoparticles. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(51): 9587-9592. [http://www.crter.cnhttp://en.zglckf.com]

Related Topics

    loading  Loading Related Articles