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Abstract

BACKGROUND:

Currently, the improvement in the effect of radiation therapy by sensitizer is one of the hotspot in tumor radiotherapy field. Chitosan has a good biocompatibility and biodegradability, and can be used as a kind of multi-functional sensitizer to apply in radiotherapy for synergy therapy.

OBJECTIVE:

To summarize the research status, application principle and development of chitosan applied in tumor radiotherapy at home and abroad recently.

METHODS:

A computer-based online search of literatures related to biological effect of chitosan published between 1995 and 2009 in CNKI database, VIP database, Wanfang database, China Biology Medicine disc, Elsevier database and PubMed database was performed. Totally 194 articles in Chinese and in English were collected. 48 of them were chosen to summarize according to inclusion criteria. The anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan were analyzed to summarize its radiosensitivity.

RESULTS AND CONCLUSION:

Chitosan has been proved to be a kind of multi-functional sensitizer for radiotherapy by the experiments of the anti-tumor effect, radiation sensitizing effect and protective effect on the normal tissues of chitosan.

RESULTS AND CONCLUSION:

Liu B, Zhang BP, Zhang H, Li ZG, Pan XJ. Application and role of chitosan in tumor radiotherapy.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011; 15(51):9643-9647. [http://www.crter.cnhttp://en.zglckf.com]

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