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Abstract

BACKGROUND:

Central airway stenosis is often treated by surgery in the past. However, some patients are not qualified for surgery, and the operation scar may lead to airway restenosis. Therefore, stent implantation becomes one of the most important means to cure central airway stenosis.

OBJECTIVE:

To summarize the clinical application progress of tracheal prosthesis and tracheal scaffold.

METHODS:

An online search of PubMed database and CNKI was performed by title-and-summary search method for relevant articles, using keywords of “tissue engineering scaffolds, artificial trachea, trachea scaffolds” in English and Chinese respectively. A total of 22 articles were retained according to inclusion criteria.

RESULTS AND CONCLUSION:

With the popularization and development of tissue engineering in recent years, research on biological tissue-engineered trachea achieved some progress. At present, tissue-engineered trachea similar to autologous trachea can be constructed using chondrocytes or bone marrow stromal cells as seed cells. Composite tissue-engineered trachea with tracheal mucosal epithelium can be constructed using chondrocytes and epithelial cells. But the long-term activities and psychological functions of tissue-engineered tracheas transplanted in vivo remain to be seen in further experiments.

RESULTS AND CONCLUSION:

Zhang RF, Chen LP. Application of tracheal prosthesis and tracheal scaffold. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(51):9651-9654. [http://www.crter.cnhttp://en.zglckf.com]

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