loading  Checking for direct PDF access through Ovid



Repair of alveolar cleft is an important part of treatment of cleft lip and palate. Composite artificial bone prepared by optimal combination based on the carrier of artificial bone has a highly osteoinductive activity and can greatly improve the treatment effect in repair of bone defects in clinic.


To evaluate the combined effects of bone morphogenetic protein-2 (BMP-2) and β-tricalcium phosphate (β-TCP) in alveolar cleft reconstruction.


Twenty-four alveolar cleft patients from Department of Stomatology, Lianyungang Second People's Hospital were divided into experimental group and control group randomly. The experimental group was repaired with BMP-2/β-TCP. The control group was repaired with autogenous iliac cancellous bone.


Incisions in both groups were with primary healing and without implant extrusion. All of the patients were followed-up for 3-6 months. Three months after surgery, bone concrescence was seen on X-ray. Part of the artificial bone was replaced by autologous bone and the bone resorption was not obvious in the experimental group after 1 year of surgery, while the bone resorption in the control group was obvious. Enemar grading standard showed that the efficacy rates of grade I in the experimental group and control group were 84% and 17% respectively, and the difference was significant (P < 0.05). It is indicated that the granulo-β-TCP/BMP-2 has the advantages of an accurate shape recovery and a low repair trauma in alveolar cleft reconstruction; the implant has a good biocompatibility, osteocondutibility and degradability, so as can be completely replaced by autologous bone and well used in alveolar cleft reconstruction.

Related Topics

    loading  Loading Related Articles