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Abstract

BACKGROUND:

Articular cartilage damage in osteoarthritis patients is related to the imbalance between matrix metalloproteinase 1 and tissue inhibitors of matrix metalloproteinase.

OBJECTIVE:

To investigate the expression of matrix metalloproteinase 1 and tissue inhibitor of matrix metalloproteinase 1 in articular cartilage and the intervention effects of Uygur medicine Maizhuni.

METHODS:

Knee osteoarthritis model was constructed using modified Hulth method. A total of 20 healthy SD rats were randomly divided into Maizhuni group and model group. Rats were treated with Uygur medicine Maizhuni or saline by gavage in the 2nd week after model construction for 4 weeks.

RESULTS AND CONCLUSION:

Compared with model group, the degree of rat knee joint cartilage degeneration in Maizhuni group was alleviated. The cartilage general score and Mankin score in Maizhuni group was lower than that in the model group (P < 0.05). The expression of matrix metalloproteinase 1 in knee joint chondrocytes of Maizhuni group decreased than that of the control group (P < 0.05); the expression of tissue inhibitor of matrix metalloproteinase 1 in Maizhuni group increased than that in the model group (P < 0.05). These findings indicate that Uyghur medicine Maizhuni may protect articular cartilage by down-regulating the expression of matrix metalloproteinase 1 and up-regulating the expression of tissue inhibitor of matrix metalloproteinase 1.

RESULTS AND CONCLUSION:

Zhang YW, Fang R, Liu ZF, Ailijiang•Asila, Meng QC. Effect of Uygur medicine Maizhuni on the expression of matrix metalloproteinase 1 and tissue inhibitor of matrix metalloproteinase 1 in the articular cartilage of rat osteoarthritis models. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(52): 9696-9700. [http://www.crter.cnhttp://en.zglckf.com]

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