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Abstract

BACKGROUND:

Deep vein thrombosis (DVT) after hip replacement operation is one of risk complications. Drug therapy is an effective way to prevent thrombosis. To achieve the best preventive effect, standardized medication program is used in clinical.

OBJECTIVE:

To summarize the prevention and treatment experience of DVT in patients after hip replacement operation.

METHODS:

Totally 110 patients who received hip replacement from Department of Orthopedics, Guyuan City People's Hospital between January 2010 and May 2011 were analyzed retrospectively. Clinical data of the patients who received low molecular weight heparin, Fondaparinux sodium, Rivaroxaban and warfarin for prevention of DVT were selected according to the requirement of China Orthopedic Surgery Venous Thromboembolism Prevention Guideline (2009 edition). Above-mentioned clinical results were compared with the clinical data from 123 patients who were also received hip replacement but were treated with drug irregularly to prevent DVT postoperatively between January 2007 and December 2009.

RESULTS AND CONCLUSION:

All the patients had no obviously uncomfortable symptoms after anticoagulant injection. Few patients with DVT in the both groups were found. D-dimer detection of 45 and 29 cases in the irregular group and the regular group were positive respectively. DVT of the two groups occurred at 4 weeks after hip replacement. Incidence of thrombosis was decreasing with the medication time. Patients with thrombosis in the regular group were obviously lower than those in the irregular group at 12 weeks after hip replacement (P < 0.05). It is indicated that to regularly use low molecular weight heparin, Fondaparinux sodium, Rivaroxaban and warfarin can efficiently prevent the occurrence of DVT after hip replacement.

RESULTS AND CONCLUSION:

Zhang Z, Fan YW, Yang YM, Wang JX. Prevention and medical treatment of deep vein thrombosis after hip replacement: A controlled trial.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(52):9764-9766. [http://www.crter.cnhttp://en.zglckf.com]

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