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Abstract

BACKGROUND:

Onset reason of the complications of diabetic osteopathia is complicated. Endothelial lesions of blood vessel in bone tissue may play an important role in onset reason.

OBJECTIVE:

To investigate the effects of diabetes on endothelial dysfunction of the femoral head in the rats.

METHODS:

Totally 60 rats were randomly divided into diabetic group and control group. Diabetic model was constructed by intraperitoneal injection of streptozotocin in the diabetic group.

RESULTS AND CONCLUSION:

Compared with the control group at 15 weeks after modeling, microstructure of the femoral head in the rats was changed, serum levels of nitric oxide level was significantly decreased, plasma endothelin 1 was significantly increased and expression of blood coagulation factorVIII was significantly decreased in the diabetic group (P < 0.01). It is indicated that the endothelial dysfunction occurs in the prediabetes. Endothelial dysfunction is induced by micrangium accrementition and diabetes, which are related with the hypofunction of the femoral head in the rats.

RESULTS AND CONCLUSION:

Zheng YT, Chen HY, Liu WG, Zhang PF. Variations of vascular endothelial dysfunction of the femoral head in diabetic rats. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(52): 9813-9816. [http://www.crter.cnhttp://en.zglckf.com]

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