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There are too many traditional analgesia methods of total knee arthroplasty (TKA), but these methods always bring some adverse events.


To evaluate the effectiveness and security of local injection of analgesic drugs around joint during TKA by Meta analysis.


PubMed, Cochrane Library, EMBASE, CNKI, CBM and WANGFANG database were searched for articles related to analgesic of total knee replacement (2000-01-01/2011-04-30). All randomized controlled trials (RCTs) about the analgesic of TKA were adopted; other treatment measures were all the same in both groups except mixed analgesics were local injected around joint during the TKA in the experimental group. Quality of literatures were critically evaluated and extracted by 2 investigators independently. The statistical analysis was conducted using the RevMan 5.1.2.


Ten RCTs involving 694 patients were collected. The results of Meta-analyses showed that compared with the traditional analgesia method, visual analogue scales (VAS) for pain during activity in the post-anesthetic-care ([WMD=−1.04, 95%CI (−1.26, −0.82), P < 0.000 01] and the VAS for pain at rest in the post-anesthetic-care [WMD=-0.67, 95%CI (-0.81, -0.54), P < 0.000 01] were lower, the number of patient needed analgesia again [RR=0.26, 95%CI (0.17, 0.40), P < 0.000 01] and morphine consumption [WMD=−6.89, 95%CI (−8.91, −4.86), P < 0.000 01] postoperatively were fewer in the experimental group. There was no significant difference of incidence adverse reactions in the two groups [RR=0.62, 95%CI(0.21, 1.84), P=0.39]. The current evidence indicated that local injection of analgesic drugs around joint after TKA is an effective and safe methods, but the effectiveness and security still need to be confirmed by RCTs with large sample.


Li Y, Cai L, Gong TF, Deng ZM, Zhang Y, Yang YB, Hu C. Meta-analysis of analgesic effect of local injection analgesic drugs around joint after total knee arthroplasty.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(52): 9823-9828. [http://www.crter.cn]

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