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The surgical reconstruction of extensive skull defect has always been a challenge for neurosurgeon for its complicated anatomical structure and irregular three-dimensional curvature. Choosing the suitable repair material to achieve perfect repairment of skull defect is the hotspot in current research.


To summarize the studies on application of concerning tissue engineering and computer associated design/computer associated manufacture (CAD/CAM) digital technology to titanium alloy materials in the repairment of cephalic injury.


A computer-based online retrieval of Medline database from January 2000 to June 2011 was performed with the key words of “tissue engineering, craniocerebral trauma, CAD/CAM, titanium armor plate” in English, and the retrieval of CNKI database from January 1990 to June 2011 was performed with the key words of “tissue engineering, skull injury, digital three-dimensional modeling, titanium mesh” in Chinese. The highly targeted articles were included. The documents published currently or in the authority journals were preferred in the same field. Studies focused on traditional materials or methods for repairing skull injury and outdated studies were excluded. The latest research and clinical practical studies were summarized in details.


A total of 236 documents were obtained in initial retrieval, 27 articles of them were chosen to summarize based on strict inclusion criteria. Traditional methods for repair of skull injury can greatly reduce the effects of restorations because of their poor biocompatibility, lack of materials, and they do not grow with the individual growth. CAD/CAM digital prototyping technology can duplicate the geometrical shape that is highly consistent with the skull and jaw defects to achieve a personalized configuration for repairing skull defects and produce well biocompatible titanium mesh skull prosthesis.


Song GY. Application of tissue engineering repair and computer associated design/computer associated manufacture digital modeling technology in skull defects.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(52): 9835-9838. [http://www.crter.cn]

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