SymbolLiver transplantation for Wilson's disease

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Abstract

BACKGROUND:

Liver transplantation can provide healthy liver tissue for Wilson's disease patients to correct their genetic defects, and it can relive clinical and neuropsychiatric symptoms induced by copper metabolism and cirrhosis.

OBJECTIVE:

To investigate the effects of liver transplantation on Wilson's disease.

METHODS:

Seventeen cases were selected. Three cases were treated with cadaveric liver transplantation, and 14 cases were treated with living-related liver transplantation. In all the cases, artery reconstruction was conducted through end-to-end anastomosis between donor hepatic artery and recipient hepatic artery. The duct-to-duct biliary reconstruction was performed, and no support pipe was placed in the biliary duct for drainage during operation.

RESULTS AND CONCLUSION:

One patient died of hemorrhage perioperatively. Fifteen patients survived more than 1 year and 10 patients survived more than 3 years. Of the eight patients with nervous system dysfunction, six patients had improved neuropsychic symptoms to various degrees after operation. The liver function and serum ceruloplasmin level were improved significantly in the 15 patients undergoing liver transplantation surviving more than 1 year (P < 0.05). It suggests that liver transplantation can correct patients' metabolic defects, which is an effective therapy for Wilson's disease.

RESULTS AND CONCLUSION:

Lü SC, Shi XJ, Liang YR, He L, Ji WB, Lu F, Chen YW, Luo Y. Liver transplantation for Wilson's disease.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(53): 9897-9900. [http://www.crter.cnhttp://en.zglckf.com]

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