SymbolChanges of urine CD54+ lymphocytes in acute rejection after renal transplantation

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Abstract

BACKGROUND:

The expression of CD54 is low in normal kidney, renal tubular epithelium and vascular endothelial cells. CD54 expression in renal tubular epithelial cells and vascular endothelial cells increases obviously when acute rejection occurres. In the meantime, the CD54 expression level in renal tubular epithelial cells increases along with interstitial renal edema and massive leukocyte infiltration.

OBJECTIVE:

To assess the value of flow cytometer detection for urine CD54+ lymphocytes in the diagnosis of acute rejection after renal transplantation.

METHODS:

Participants were renal transplant recipients from General Hospital of Chengdu Military Area Command of Chinese PLA, including patients obtained normal renal function (n=18), patients with acute rejection (n=8) and patients with graft dysfunction (n=9). Healthy volunteers were included as control (n=10). Urine CD54+ lymphocyte rates of each group were compared by flow cytometer before and after transplantation.

RESULTS AND CONCLUSION:

The expression of urine CD54+ lymphocytes in renal transplant recipients increased significantly during the rejective time (P < 0.01), and reduced gradually after anti-rejction treatment. The expression of CD54 increased moderately in patients obtained normal renal function and patients with graft dysfunction. These findings indicate that CD54+ lymphocyte level in urine can accurately reflect the immune condition of renal transplant recipients and could be used as a specific parameter in the diagnosis of acute rejection after renal transplantation.

RESULTS AND CONCLUSION:

Li SD, Wang L, Wang QT, Chen WG, Yang H, Zhou P, Liang P, Li XW. Changes of urine CD54+ lymphocytes in acute rejection after renal transplantation. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(53): 9905-9908. [http://www.crter.cnhttp://en.zglckf.com]

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