SymbolEffects of oral administration of donor spleen cells on kidney transplantation in rats

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Abstract

BACKGROUND:

It is proved that oral administration of donor antigen can induce immunology tolerance effectively. The spleen is the biggest human lymphoid organ containing many T lymphocytes and can provide abound antigens.

OBJECTIVE:

To observe the effects of oral administration of donor spleen cells on rat kidney function after transplantation.

METHODS:

Before kidney transplantation, Lewis (RT11) rats in splenocytes group were fed with 5×105 donor splenocytes by gastric intubation daily for 7 days, while Lewis (RT11) rats in transplantation group were fed with 1 mL PBS as control.

RESULTS AND CONCLUSION:

On the 5th day after transplantation, allografts rejection symptoms began appearing in the transplantation group. Mean survival time of splenocytes group was longer than that of the transplantation group. After transplantation, the serum creatinine and urea nitrogen level in splenocytes group increased slower than that in the transplantation group. According to hematoxylin-eosin staining, the acute rejection occurred earlier in transplantation group than that in the splenocytes group. It demonstrates that oral administration of donor spleen cells can induce immune tolerance and prolong the survival time of kidney allografts.

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