SymbolProteinuria after kidney transplantation

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Abstract

BACKGROUND:

Proteinuria directly correlates with long-term survival of transplanted kidney and is an independent risk factor influencing long-term survival of transplanted kidney and leading to death of transplant patients.

OBJECTIVE:

To investigate the effects of angiotensin II receptor blocker combined with tripterygium glycosides in treatment of proteinuria after kidney transplantation.

METHODS:

Forty-five patients presenting with proteinuria after kidney transplantation were divided into three groups: treatment, tripterygium glycosides group and control. In the treatment group, based on conventional application of immunosuppressive agent, 2-fold dose of angiotensin II receptor blocker combined with tripterygium glycosides (1 mg/kg per day) were used. In the tripterygium glycosides group, tripterygium glycosides (1 mg/kg per day) was used. In the control group, only immunosuppressive agent was used.

RESULTS AND CONCLUSION:

At 12 months after treatment, 24-hour urine protein, ciclosporin A concentration, ciclosporin A dosage were significantly lower in the treatment and tripterygium glycosides groups than in the control group (P < 0.05). After treatment, urea nitrogen and creatinine levels in the treatment group were significantly lower than those in the control and tripterygium glycosides groups (P < 0.05). These findings suggest that angiotensin II receptor blocker combined with tripterygium glycosides can obviously decrease urine protein level after kidney and reduce immunosuppressive agent application dose, exhibiting a protective effect on transplanted kidney.

RESULTS AND CONCLUSION:

Shen BL, Yang L, Hu JJ, Wang SJ, Xie HM, Guo XF. Proteinuria after kidney transplantation. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(53): 9953-9956. [http://www.crter.cnhttp://en.zglckf.com]

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