SymbolCryopreservation of the lung from a non-hear-beating donor

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Abstract

BACKGROUND:

There are two ways to cryopreserve the lung from non-heart-beating donors: one is in situ thoracic cavity internal surface cooling technique, which has been confirmed by successful transplantation in the clinic, and the other is in situ endotracheal venting cooling technique.

OBJECTIVE:

To evaluate the feasibility of combining in situ thoracic cavity internal surface cooling technique with in situ endotracheal venting cooling technique in cryopreserving the lung from non-heart-beating donor.

METHODS:

Wister rats were randomly divided into three groups: in situ endotracheal venting hypothermy group (venting group), cool gas was insufflated into the trachea; in situ thoracic cavity internal surface hypothermy group (surface group): cool physiological saline was persistently injected into bilateral thoracic cavity; and combination group: cool gas insufflation combined with physiological saline injection into bilateral thoracic cavities

RESULTS AND CONCLUSION:

The combination group produced better effects than the surface group and venting group (P < 0.05), and the temperature of trachea and lung parenchyma could be lowered to preservation temperature within 60 minutes. These findings suggest the feasibility of in situ thoracic cavity internal surface cooling technique and in situ endotracheal venting cooling technique used in lung transplantation.

RESULTS AND CONCLUSION:

Dong Q, Cui J, Han JQ, Yan YB, Cao SQ, Zhang K. Cryopreservation of the lung from a non-hear-beating donor. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(53): 9965-9968. [http://www.crter.cnhttp://en.zglckf.com]

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