SymbolCorrelation between renal arterial hemodynamic alterations and renal functions evaluated by color Doppler ultrasound using a rabbit renal ischemia reperfusion model

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Abstract

BACKGROUND:

Previous diagnosis of renal ischemia reperfusion mainly depends on biochemical and pathological examination. Color Doppler flow imaging (CDFI) can mini-invasively rapidly display renal blood flow changes following renal ischemia/reperfusion injury.

OBJECTIVE:

To evaluate rabbit renal arterial hemodynamical changes after renal ischemia reperfusion using CDFI, and analyze the correlation between arterial hemodynamical changes and renal function indices including blood urea nitrogen (BUN) and creatinine (Cre).

METHODS:

Fifty-six rabbits were randomly divided into normal control group, ischemia reperfusion group and sham operation group. Rabbits were established into renal ischemia reperfusion models in the ischemia reperfusion group. Rabbits in the sham operation group underwent resection of the right kidney. No treatment was performed in the control group. According to different time points, three subgroups were used in the former two groups.

RESULTS AND CONCLUSION:

With aggravation of renal ischemia reperfusion injury, the systolic velocity, pulsatility index, resistance index and BUN and Cre were gradually increased and reached the peak at 24 hours. Hemodynamical changes first appeared in the interlobar artery. Resistance index is the most sensitive index to reflect the degree of renal ischemia reperfusion injury. CDFI is an effective method to evaluate renal ischemia/reperfusion injury degree.

RESULTS AND CONCLUSION:

Xuan JQ, Peng LQ, Li MX, Li KP, Luo ZJ. Correlation between renal arterial hemodynamic alterations and renal functions evaluated by color Doppler ultrasound using a rabbit renal ischemia reperfusion model.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(53): 9981-9985. [http://www.crter.cnhttp://en.zglckf.com]

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