SymbolInfection and rejection after small intestine transplantation

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Abstract

BACKGROUND:

Small intestine transplantation has been conducted in some transplantation centers of China and obtained favorable short-term effects. However, complications are critical for success of transplantation, and effective prevention and early treatment of complications are important for small intestine transplantation.

OBJECTIVE:

To discuss causes for posttransplant infection and rejection and prevention measures.

METHODS:

With key words “Small bowel transplantation; Liver bowel transplantation; Rejection; Immunosuppressive; Infection” in English and Chinese, a computer-based online search of Medline and CNKI was performed for articles related to infection and rejection after small intestine transplantation published between January 2000 and June 2011. A total of 25 articles were included.

RESULTS AND CONCLUSION:

The small intestine contains abundant lymphatic tissues and a large number of immune competent cells. Moreover, there are a large amount of microorganisms in the enteric cavity, inducing high incidence of rejection and infection following transplantation. Reduction of complications is based on prevention and treatment time. Monitor of cytokines changes can prevent rejection following small intestine transplantation.

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