SymbolEffects of different preservation methods on the immunogenicity of cartilage allografts in the repair of cartilage defects

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Abstract

BACKGROUND:

Immune rejections still exist in the allograft cartilage transplantation for repair of cartilage defects.

OBJECTIVE:

To evaluate the effects of programmed cryopreservation method, cryoprotective agent process for cooling preservation, tissue culture method, and chemical treatment on the immunogenicity of cartilage allografts in the repair of cartilage defects.

METHODS:

An electronic search of Wanfang and PubMed was performed for articles about effects of different preservation methods on the immunogenicity of cartilage allografts in the repair of cartilage defects published 1998-01/2011-11. The keywords were “cartilage, preservation, transplantation”. Repetitive studies, reviews and Meta analysis were excluded, and finally 36 articles were included.

RESULTS AND CONCLUSION:

Chondrocyte membrane has histocompatibility antigens, and chondrocytes can be expressed in the major compatibility complex with specific differentiation antigens. When the matrix is tact, the cartilage cells cannot touch receptor lymphocytes and plasma cells, showing a low immunity, but the subchondral bone was not covered with the matrix. As a result, the cartilage allografts with the subchondral bone can immunogenicity, though the fixation can be strengthened. The programmed cryopreservation method, cryoprotective agent process for cooling preservation, and tissue culture method have achieved good effects on the immunogenicity of cartilage allografts in the repair of cartilage defects.

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