SymbolImmune rejection following anterior cruciate ligament reconstruction with tendon allograft

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Abstract

BACKGROUND:

In recent years, tendon allograft is gradually used for repair of anterior cruciate ligament injury.

OBJECTIVE:

To review the characteristics of anterior cruciate ligament injury and immune rejection following anterior cruciate ligament reconstruction with tendon allograft.

METHODS:

A computer-based search of PubMed and VIP databases (1990-01/2011-10) was performed for relevant articles using the keywords of “anterior cruciate ligament, allograft, anatomy, transplantation” in English and “anterior cruciate ligament, allograft, tendon, transplantation” in Chinese. Totally, 164 articles were retrieved, and finally 34 articles were included in result analysis.

RESULTS AND CONCLUSION:

Over the past several decades, domestic and foreign scholars have studied anterior cruciate ligament reconstruction with tendon allograft and gradually understood the biomechanical properties of the anterior cruciate ligament. Freezing method and cell toxic treatment method are employe d to solve the immune rejection following allogeneic tendon grafting, not only to reduce the antigenicity of allogeneic tendon, but also to save the activity of tendon cells, promote endogenous tendon healing, improve tendon healing and strength, reduce or avoid the occurrence of tendon adhesions, and achieve good clinical results.

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