SymbolAllogeneic tendon graft for repair of sports injuries: Immune rejection and methods to reduce immune rejections

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Abstract

BACKGROUND:

Allogeneic tendons are of plenty source and easy to obtain, which maintain the original biological characteristics structure and meet the requirements for physique and quantity. However, untreated tendon allograft has a great immune rejection after transplantation.

OBJECTIVE:

To evaluate the repair effect of allogeneic tendon graft, and to summarize the methods to reduce immune rejections.

METHODS:

A computer-based search of Wanfang database was performed for articles published 1990-01/2011-11 addressing the immune rejection and methods to reduce the immune rejection after the allogeneic tendon graft for repair of sports injuries. The keywords were “allogeneic, tendon, construction”. Repetitive studies, review and Meta analysis were excluded, and finally 33 articles were included.

RESULTS AND CONCLUSION:

Histocompatibility of allogeneic tendon graft is poor, leading to a strong immune rejection. The graft can have tendon necrosis, immune rejection and other negative phenomena after transplantation of an untreated allogeneic tendon, resulting in a higher rate of graft failure. Methods to reduce the immune rejection are mainly as follows: frozen allograft tendons, freeze-dried allograft tendon, tendon soaked in drugs, and radiation sterilization method to save the tendon. It is noted that immune rejection following allogeneic tendon graft is the most difficult clinical problem, but frozen allograft tendons and other methods are good to solve this problem, and play a good clinical effect.

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