Symbolone case of Penicillium marneffei infection after kidney transplantation

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Abstract

BACKGROUND:

Due to the application of immunosuppressants and broad-spectrum antibiotics after kidney transplantation, complicated infected pathogen emerges, illness becomes serious and death rate is high. Therefore, it is the key to improve infection cure rate by raising awareness of pathogenic characteristics of rare bacteria combined after kidney transplantation and early appropriate treatment.

OBJECTIVE:

To investigate the clinical characteristics and treatment of Penicillium marneffei infection after kidney transplantation.

METHODS:

Clinical data, predisposing factors, pathogenic characteristics and treatment of one kidney transplantation patient were analyzed retrospectively in June 2010.

RESULTS AND CONCLUSION:

Clinical manifestations with chills, fever, oliguria, abdominal distension, cough, sputum, weight loss and fatigue were shown in the patient. Blood routine examination: white blood cells (1.42-2.51)×109/L, hemoglobin 66-83 g/L, platelets (21-43)×109/L, C-reactive protein 179.0-212.0 mg/L, procalcitonin-u 17.2-28.9 μg/L. The growth of Penicillium marneffei was shown in the chest, ascites and blood culture. But the symptoms were not improved after 250 mg/d intravenous infusion of itraconazole, suspension of immunosuppressants and immune support with gamma globulin and thymosin. Eventually, the patient gave up the treatment because of respiratory and circulatory failure. Clinical cases of Penicillium marneffei infection after kidney transplantation are rare, so the cinician have a little understanding of it. Thus, there is in demand for a consideration to the Penicillium marneffei infection for patients who have extremely low immune function with recurrent fever and multiple organ dysfunctions. Biphasic fungal culture and antigen determination if permitted need to be done for early diagnosis.

RESULTS AND CONCLUSION:

Chen TQ, Kong YZ, Luo QW, Lin MW, Xu JW. One case of Penicillium marneffei infection after kidney transplantation.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(53): 10068-10070. [http://www.crter.cnhttp://en.zglckf.com]

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