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Abstract

BACKGROUND:

Uric acid (UA) plays different roles on different cells. But, what is the effect of UA on the proliferation of human placenta-derived mesenchymal stem cells (hPMSCs), promoting or suppression?

0BJECTIVES:

To observe the effect of UA on proliferation of hPMSCs, and to explore the relationship between time-effect and dose-effect.

METHODS:

The hPMSCs cultured in vitro were used and divided into 6 groups: the control group and the UA group which contained 0.1, 0.2, 0.4, 0.6, 0.8 mmol/L UA.

RESULTS AND CONCLUSION:

MTT assay showed that the number of hPMSCs in 0.1, 0.2, 0.4, 0.6, 0.8 mmol/L UA group was more than that in the control group at the same time, especially in 0.8 mmol/L UA group; the number of hPMSCs in same concentration of UA was increasing following the time (time<5 d), and reached to peak at the 5th day. UA could accelerate the proliferation of hPMSCs and showed a time- and dose-dependent manner, and the effect of 0.8 mmol/L UA on the proliferation capacity of hPMSCs was stronger than others at the 5th day.

RESULTS AND CONCLUSION:

Cui J, Yang NL, Wang JY. Effect of uric acid on proliferation of human placenta-derived mesenchymal stem cells.Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(10): 1795-1798. [http://www.crter.cnhttp://en.zglckf.com]

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