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Abstract

BACKGROUND:

The synergy of various cell growth factors attracts more and more attention in the course of cartilage metabolism. However, there are few reports of repairing cartilage defects with combined cell growth factors, and the effect remains unknown at present.

OBJECTIVE:

To study the repairing effect of recombinant human bone morphogenetic protein (rhBMP) combined with basic fibroblast growth factor (bFGF) on articular cartilage defects.

METHODS:

After the model of articular cartilage defects was made, 24 Japan big-eared white rabbits were randomly divided into four groups for intervention: rhBMP combined with bFGF (group A), single rhBMP (group B), single bFGF (group C), the fourth group was without injection and just filled with gelatin sponge (group D).

RESULTS AND CONCLUSION:

In general observation, articular cartilage defects were basically repaired but slightly uneven in group A, and there were no defects entirely repaired in groups B and C. In group D, articular cartilage defects were not repaired. The number of cartilage cells in group A was more than that in groups B, C and D (P < 0.05). The positive number of type II collagens by immunohistochemical staining in group A was higher than that in the other groups. It indicated that rhBMP combined with bFGF could accelerate the formation of new articular cartilage, and had better effect than rhBMP or bFGF alone.

RESULTS AND CONCLUSION:

Zhu GH, Cai JP, Guo CL, Liao JX, Liu Y, Luo HT, Xu GH, Hu HT. Effects of recombinant human bone morphogenetic protein combined with basic fibroblast growth factor on the repair of articular cartilage defects. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(11): 1910-1914. [http://www.crter.cnhttp://en.zglckf.com]

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