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Expression of interleukin-17 increases in many cardiovascular disease such as autoimmune myocarditis, viral myocarditis, dilated cardiomyopathy and unstable coronary artery disease. Interleukin-17 plays an important role in chronic inflammatory process of cardiovascular diseases.


To study the expression of interleukin-17 in the myocardium after myocardial infarction in rats.


Liquid nitrogen freezing method was used to establish a rat myocardial infarction model. Totally 66 rats with modeling successful were randomly divided into six groups according to different observation times: 1, 3, 7, 14, 28, 56 days groups. And eight rats were selected as controls. The expression of interleukin-17 was examined by enzyme linked immunosorbent assay, laser confocal scanning microscope and Western blot.


Modeling success rate was 73%. With the development of myocardial infarction, interleukin-17 was abundantly expressed in the myocardial tissue and gradually increased over time. The expression of interleukin-17 in the 28 days group increased most significantly. Interleukin-17 as a potent pro-inflammatory factor can strongly express in rat myocardium after myocardial infarction, which may be related to the incidence of ventricular remodeling and arrhythmia.


Chen ZZ, Chen ZJ, Zeng QT, Liu XG, Zhang Q, Liu LX, Zhu YT, Qian C, Du YM, Zhao N. Expression of interleukin-17 in the myocardium of rats with myocardial infarction. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(11): 1985-1988. [http://www.crter.cn]

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