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Abstract

BACKGROUND:

Expression of interleukin-17 increases in many cardiovascular disease such as autoimmune myocarditis, viral myocarditis, dilated cardiomyopathy and unstable coronary artery disease. Interleukin-17 plays an important role in chronic inflammatory process of cardiovascular diseases.

OBJECTIVE:

To study the expression of interleukin-17 in the myocardium after myocardial infarction in rats.

METHODS:

Liquid nitrogen freezing method was used to establish a rat myocardial infarction model. Totally 66 rats with modeling successful were randomly divided into six groups according to different observation times: 1, 3, 7, 14, 28, 56 days groups. And eight rats were selected as controls. The expression of interleukin-17 was examined by enzyme linked immunosorbent assay, laser confocal scanning microscope and Western blot.

RESULTS AND CONCLUSION:

Modeling success rate was 73%. With the development of myocardial infarction, interleukin-17 was abundantly expressed in the myocardial tissue and gradually increased over time. The expression of interleukin-17 in the 28 days group increased most significantly. Interleukin-17 as a potent pro-inflammatory factor can strongly express in rat myocardium after myocardial infarction, which may be related to the incidence of ventricular remodeling and arrhythmia.

RESULTS AND CONCLUSION:

Chen ZZ, Chen ZJ, Zeng QT, Liu XG, Zhang Q, Liu LX, Zhu YT, Qian C, Du YM, Zhao N. Expression of interleukin-17 in the myocardium of rats with myocardial infarction. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(11): 1985-1988. [http://www.crter.cnhttp://en.zglckf.com]

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