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At present, the principle and procedure for the treatment of tumor invading suprarenal and infrarenal inferior vene cave (IVC) are in dispute, but corresponding animal model is rarely reported in the literatures.


To establish the experimental animal model of the VX2 tumor invading suprarenal and infrarenal IVC, and to observe the influence on tumor growth and the IVC and abdominal aorta (AA).


Twenty-four rabbits were randomly divided into suprarenal group and infrarenal group, the prepared VX2 tumor tissue mass was transplanted into the soft tissues around the suprarenal and infrarenal IVC. Tumor size, diameter of the IVC and the AA, and the surrounding tissues were detected by ultrasound once a week as long as 5 weeks after implanted.


All VX2 tumors had been growing successfully in the experimental rabbits. Tumor size was significantly positive related to the growth time in two groups (r1=0.894, r2=0.879); the diameter of the IVC and AA were significantly negative related to tumor size in two groups (r3=-0.663, r4=-0.834; r5=-0.826, r6=-0.870). The difference of tumor size was not significant between two groups (P1=0.293>0.05). In the observation period, the stenosis of IVC was less than 50% in suprarenal group; the IVC in infrarenal group was completely blocked and effectively avoided the pressure on the AA. VX2 tumor tissue mass transplanted into the soft tissues around the infrarenal IVC leads to an ideal animal model.


Zhang YG, Ren W. Establishment of an inferior vene cava animal model by VX2 tumor implanted into the suprarenal and infrarenal vein in rabbits. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(11): 1999-2002. [http://www.crter.cn]

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