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Abstract

BACKGROUND:

Phyllanthus Emblica has a significant hypoglycemic effect. However, its mechanism is not clear.

OBJECTIVE:

To explore the effects of Phyllanthus Emblica extracts on the proteins related to the insulin signal pathway in rat bone and fat tissues.

METHODS:

A total of 30 SD rats were randomly divided into control group, model group and Phyllanthus Emblica group. Rats in the latter two groups were intraperitoneally injected with streptozotocin to construct diabetic model. Rats in the Phyllanthus Emblica group were administrated with Phyllanthus Emblica extracts by gavage for 6 weeks; rats in the model group and the control group were administrated with distilled water of the same volume by gavage.

RESULTS AND CONCLUSION:

Compared with the control group, the body mass, fasting blood glucose, fasting insulin and insulin resistance index in diabetic rats increased significantly (P < 0.05); while the mRNA and protein levels of phosphatidylinositol-3-kinase, protein kinase B and glucose transporter 4 in the fat and muscle tissues decreased significantly (P < 0.05, P < 0.01). The body mass, fasting blood glucose, fasting insulin and insulin resistance index in the Phyllanthus Emblica rats at 6 weeks after the gavage of Phyllanthus Emblica extracts was lower than those of the model rats; while the mRNA levels of phosphatidylinositol-3-kinase, protein kinase B and glucose transporter 4 in fat and muscle tissues increased significantly (P < 0.01, P < 0.05). The protein expression of glucose transporter 4 in the fat tissues increased (P < 0.01). However, there was no significant difference between the protein expressions of glucose transporter 4 in the muscles. These findings indicate that Phyllanthus Emblica extracts can achieve hypoglycemic effects by regulating insulin-mediated phosphatidylinositol-3- kinase/protein kinase B/glucose transporter protein 4 signal transduction pathway.

RESULTS AND CONCLUSION:

Hu W. Effects of Phyllanthus Emblica extracts on the insulin signal pathway in muscle and fat tissues of diabetic rats. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(11): 2007-2010. [http://www.crter.cnhttp://en.zglckf.com]

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