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While the cellular and molecular mechanisms of wound healing have been understood gradually and the experiences of wound bed management have been accumulated, the importance of wound bed preparation to wound repair has recently attracted more attention.


To fully analyze the mechanisms of wound healing, various influence factors and their effects in this progress.


An on line search of CNKI and PubMed databases was performed for articles published between 1994 and 2011, using key words of “TIME principles, wound bed preparation, wound healing” in Chinese and English, respectively. The clinical application principles and outcomes of wound healing were analyzed.


A total of 498 papers were collected, and 24 of them were included according to inclusive criteria. TIME is the initials of four principles in wound bed management. T means to remove the necrotic tissue. I means to control the infection and to reduce the inflammation. M means to keep the wound moisture under normal condition for the granulation tissue growth and re-epithelialization. E means to remove non migrating epidermis at the edge of wound. As a valuable guidance tool for wound management, the TIME concept has been applied to clinical practice, and has been widely appreciated by clinicans.


Xu Y, Liu HW. “TIME” principles and its clinical significance in wound repair. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(11): 2059-2062. [http://www.crter.cn]

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