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Abstract

BACKGROUND:

Acellular dermal matrix is available for burn, hernia repair, breast reconstruction, soft tissue reconstruction, etc. Research of repair for bile duct injury with acellular dermal matrix has not been previously reported in the recent literature.

OBJECTIVE:

To observe acellular dermal matrix effect on the repair of bile duct injury in Diannan small-ear pigs.

METHODS:

Bile duct injury models were established in 72 Diannan small-ear pigs which were randomly divided into three groups and treated with biliary intestinal anastomosis, expanded polytetrafluorethylene and acellular dermal matrix, respectively.

RESULTS AND CONCLUSION:

Total bilirubin level in the acellular dermal matrix group was lower than that in the other two groups at 2-4 months after treatment (P < 0.05). The expression of transforming growth factor β1 in the acellular dermal matrix group was higher as compared with the other two groups at 1-4 months after treatment (P < 0.05), and it decreased along with time passing. Regeneration of biliary epithelial cells, gland, vascular endothelial cells and smooth muscle, even nerve was detected in the acellular dermal matrix group under light microscope and electron microscope. No similar detection occurred in other groups. biliary stricture, infection and rejection were not found in the acellular dermal matrix group. These findings suggest that acellular dermal matrix can be used to physiologically repair bile duct defects with less complications and good biocompatibility.

RESULTS AND CONCLUSION:

Chen G, Bai JH, Liu QY, Li XY, Zhu XF, Wang Q, Zhao YP, Li JF, Li L. Acellular dermal matrix for the repair of bile duct injury in Diannan small-ear pigs. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(12): 2141-2144. [http://www.crter.cnhttp://en.zglckf.com]

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