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Searching for the repair materials with good biological characteristics for bone tissue engineering has been a hot spot of orthopedic research. Although there are various kinds of bone repair materials and methods, but none of them can perfectly replace the human bone.


To review the tissue engineering research which focuses on using titanium plate, titanium mesh bone grafting to repair bone damage.


An online search of CNKI and Medline databases was performed using the key words of “tissue engineering”, “artificial bone repair”, “titanium plate” and “titanium mesh bone grafting” for related articles published between January 2000 and October 2011. Related articles published in recent years were included; as to the same field, articles published recently or in authoritative magazines were selected. Outdated literatures and articles on bone defect repair using traditional materials or methods were excluded. Most recent studies and articles with practical value were collected, analyzed in detail and summarized.


A total of 201 articles were collected after the preliminary search; 27 of them were retained according to the inclusion criteria. Using traditional methods to repair damaged bone often encounter many problems, such as poor tissue compatibility, lack of materials and can not match the individual growth, which greatly reduce the application effect of the restoration. Titanium mesh bone grafting is easy to operate, has small rejection; it can be shaped arbitrarily and stable osseointegration with the host bone is achieved after implantation. In addition, titanium mesh bone grafting can create a solid base of support. Therefore, satisfied repairing effects of bone defects can be achieved using titanium mesh bone grafting.


Liu Y, Ma XL. Application of synthetic bone-repair materials and titanium metallic materials in bone tissue engineering. Zhongguo Zuzhi Gongcheng Yanjiu.

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