SymbolChitosan inhibits traumatic proliferative vitreoretinopathy in rabbits

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Abstract

BACKGROUND:

The research has found that chitosan can inhibit the scar formation in glaucoma surgery. However, there is not yet a clear report whether chitosan can prevent and slow the formation of proliferative vitreoretinopathy (PVR).

OBJECTIVE:

To investigate the effect of chitosan on traumatic PVR in rabbits and its mechanism.

METHODS:

Rabbit traumatic PVR model was made by intravitreal injection of platelet-rich plasma. Subsequently, the rabbit vitreous body received an intravitreal injection of 0.1 mL normal saline, 5%, 10% and 15% chitosan. The preventive and therapeutic effect of chitosan on traumatic PVR was examined at different time points.

RESULTS AND CONCLUSION:

In the control group, the retina was detached after 10 days; the PVR had progressed to high stage over time. In chitosan group, the PVR also developed; however, the severity of PVR in chitosan group was lower than that in control group. The clinical grading of traumatic PVR in 10% and 15% chitosan group was significantly lower than that in the control group at 5 days after injection (P < 0.05). Histological examination showed that there was no obvious morphological change of the retina in chitosan group. Intravitreal injection of chitosan is a safe and effective mean to reduce the development of traumatic PVR.

RESULTS AND CONCLUSION:

Feng Y, Wang WH. Chitosan inhibits traumatic proliferative vitreoretinopathy in rabbits. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1341-1344. [http://www.crter.cnhttp://en.zglckf.com]

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