SymbolChitosan inhibits traumatic proliferative vitreoretinopathy in rabbits

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The research has found that chitosan can inhibit the scar formation in glaucoma surgery. However, there is not yet a clear report whether chitosan can prevent and slow the formation of proliferative vitreoretinopathy (PVR).


To investigate the effect of chitosan on traumatic PVR in rabbits and its mechanism.


Rabbit traumatic PVR model was made by intravitreal injection of platelet-rich plasma. Subsequently, the rabbit vitreous body received an intravitreal injection of 0.1 mL normal saline, 5%, 10% and 15% chitosan. The preventive and therapeutic effect of chitosan on traumatic PVR was examined at different time points.


In the control group, the retina was detached after 10 days; the PVR had progressed to high stage over time. In chitosan group, the PVR also developed; however, the severity of PVR in chitosan group was lower than that in control group. The clinical grading of traumatic PVR in 10% and 15% chitosan group was significantly lower than that in the control group at 5 days after injection (P < 0.05). Histological examination showed that there was no obvious morphological change of the retina in chitosan group. Intravitreal injection of chitosan is a safe and effective mean to reduce the development of traumatic PVR.


Feng Y, Wang WH. Chitosan inhibits traumatic proliferative vitreoretinopathy in rabbits. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1341-1344. [http://www.crter.cn]

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