SymbolSecurity and biocompatibility of injectable absorbable poly amino acid/calcium sulfate compositesin vivo

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Abstract

BACKGROUND:

Injectable bone repair materials such as polymethylmethacrylateand calcium phosphate cement cannot be completely degraded or absorbed in clinical application, and both of them have poor osteogenic ability.

OBJECTIVE:

To evaluate the security and biocompatibility of injectable absorbable poly amino acid/calcium sulfate through animal experiments.

METHODS:

The composite materials were implanted into the musculus sacrospinalis of New Zealand rabbits, and the diffusion solution was injected into Kunming mice and the back skin of New Zealand rabbits, respectively.

RESULTS AND CONCLUSION:

The general condition of mice were good after the injection of the diffusion solution, and the body weight was increasing, without significant edema, adhesions, necrosis of intra-abdominal organs. The skin stimulation reactions such as erythema and edema were not observed after the injection of the diffusion solution into the rabbits. The inflammatory reaction around the implants was obvious after intramuscular implantation into the rabbits in the early stage, and then weakened gradually. The capsule-like structure was also absorbed gradually, and no significant rejection was observed. The activity of cytochrome oxidase and lactate dehydrogenase of muscles cells around the implants had no significant decrease after implantation. All of the above prompted that the new poly amino acid/calcium sulfate composites have good biocompatibility and excellence safety in vivo.

RESULTS AND CONCLUSION:

Zou C, Zhang S, Duan H, Min L, Zhou Y, Tu CQ, Yan YG, Pei FX. Security and biocompatibility of injectable absorbable poly amino acid/calcium sulfate composites in vivo. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1391-1395. [http://www.crter.cnhttp://en.zglckf.com]

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