SymbolLocal reaction of endometrium after the implantation of Cu-intrauterine device into the urterine horn: Early- and late-stage evaluation

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Abstract

BACKGROUND:

Many reports have shown that the clinical application of Cu-intrauterine device (Cu-IUDs) can lead to the morphological change of endometrium and adverse reaction. However, no literatures at home or abroad have reported the pathological changes of endometrium after implantation of Cu-IUDs evaluated by in situ animal experiment.

OBJECTIVE:

To evaluate the local reaction after in situ implantation of Cu-IUDs into rat back muscles and urterine horn.

METHODS:

The Cu-IUDs were implanted into rat back muscles and urterine horn respectively. In the back muscle group, two titanium standard reference substances and two Cu-IUDs samples were implanted in the left and right back muscle respectively; in the urterine horn group, the titanium standard reference substances and Cu-IUDs samples were implanted into different rats. At 1, 4, 12 and 26 weeks postoperatively, the histological changes of different implantation parts were observed by hematoxylin-eosin staining.

RESULTS AND CONCLUSION:

①General observation after Cu-IUDs implanted in the back muscles showed that the samples were wrapped by thick capsular space. When the capsules were incision, viscous white liquor puris could be seen, the capsule wall of the reference substances was thinner than that of the samples; the capsule wall of the samples was thicker than that of the reference substances, necrotic neutrophilic granulocyte based pus cells formation and macrophages and lymphocytes could be seen in the capsule wall; the capsule wall of the reference substances was thinner, there were only several layers of fiber cells, no inflammatory cells. ②General observation after the Cu-IUDs implanted in the urterine horn showed that there were no obvious substantive lesions on the implanted part in sample group and control group. Samples and reference substances were intact and no inflammatory reaction. Pathological observation showed that neutrophilic granulocyte based inflammatory response could be seen in the local part in the early stage and macrophages and lymphocytes based chronic inflammation reaction could be seen in the late stage as well as the squamous metaplasia phenomenon of uterine endothelial cells. In the control group, there were no inflammatory response cells in the early stage; the chronic inflammation reaction could be seen in the late stage, but slighter than that in the sample group. After being implanted intramuscularly, the product samples induced massive suppurative inflammation which is relate to the material properties, the method is not suitable for the evaluation of Cu-IUDs. After being implanted in situ within horn of uterus, the product samples induced acute inflammatory reaction in the early stage and chronic inflammatory reaction in the late stage, which was accompanied by squamous metaplasia, in situ implantation is closer to clinical practice.

RESULTS AND CONCLUSION:

Zhang H, Wang ZX. Local reaction of endometrium after the implantation of Cu-intrauterine device into the urterine horn: Early-and late-stage evaluation. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(8): 1407-1412. [http://www.crter.cnhttp://en.zglckf.com]

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